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P38α is a Ser/Thr protein kinase involved in a variety of cellular processes and pathological conditions, which makes it a promising pharmacological target. Although the activity of the enzyme is highly regulated, its molecular mechanism of activation remains largely unexplained, even after decades of research. By using state-of-the-art molecular dynamics simulations, we decipher the key elements of the complex molecular mechanism refined by evolution to allow for a fine tuning of p38α kinase activity. Our study describes for the first time the molecular effects of different regulators of the enzymatic activity, and provides an integrative picture of the activation mechanism that explains the seemingly contradictory X-ray and NMR data.

P38 Ser/Thr kinases are mitogen-activated protein kinases (MAPKs) involved in the regulation of multiple cellular processes, including cell proliferation, differentiation, senescence, and death (). The p38 subgroup of MAPKs comprises four members (α-δ) where only p38α is expressed ubiquitously at high levels (). P38 signaling is strongly activated by environmental stresses (e.g. Osmotic shock, ionizing radiation), and biological stimuli, such as growth factors and inflammatory cytokines (). Furthermore, p38α has been implicated in several pathological conditions, for example, chronic inflammatory diseases, cancer, and heart and neurodegenerative diseases (, ), which is why elucidation of its activation mechanism is of therapeutical importance (; ). Like most kinases, p38α is composed of two lobes: the smaller N-terminal lobe, consisting mostly of β-sheets, and the α-helical C-terminal lobe. The lobes are linked by a flexible hinge that forms the ATP-binding site together with structural elements from both lobes (marked regions in ).

In the canonical activation pathway, MAPK kinases (MAP2Ks) dually phosphorylate the TGY sequence in the activation loop (A-loop; and ) which, according to X-ray crystallography (), triggers its large conformational rearrangements and the formation of a characteristic β-sheet motif away from the ATP- and substrate-binding sites (). The new position of the A-loop brings N- and C-lobes closer and facilitates the reorientation of key residues which participate in the stabilization of ATP and the catalytically crucial Mg 2+ ions () (i.e. The universally conserved K53, E71, and D168). Moreover, p38α and other MAPKs possess two distinct structural elements (): (1) the MAPK insert (MKI), which forms a lipid-binding site () and (2) the L16 loop that extends from the C-lobe to the N-lobe where it folds into the C-terminal L16 helix.